Healthspan & Longevity | Chronic Inflammation | Mast Cell Modulation
There are rare moments when political urgency, scientific progress, and cultural appetite collide — creating the conditions for real transformation. This may be one of them. With skyrocketing healthcare costs, rising rates of chronic disease, and declining life expectancy, America finds itself at a crossroads. The appointment of Robert F. Kennedy Jr. as Secretary of Health and Human Services under the new Trump administration has made headlines, but behind the headlines lies something more consequential: a mandate. Sources close to the administration confirm that Kennedy has been tasked with producing statistically significant improvements in the health of Americans within 12 to 18 months — a task that will require reimagining the entire foundation of modern healthcare
And yet, this may be exactly what Kennedy has been preparing for. For years, he has been a vocal critic of the status quo, warning that America’s obsession with treating disease after the fact — rather than preventing it — is not only bankrupting the system but robbing Americans of their vitality. “We have a crisis of chronic disease in this country, and it’s bankrupting us — financially and spiritually,” Kennedy has said. His charge is simple, but not easy: find technologies and interventions that work fast, measurably, and at scale to reverse the tide.
Enter the Global Passion Project, a gathering place for innovators who are collectively rethinking how we approach health, vitality, and longevity. The summit this year in Palm Beach could not be more timely, as Kennedy and his team will be watching closely for ideas that could spark the kind of rapid transformation he is tasked with delivering.
Among the thought leaders stepping onto this stage is Jackie Iversen, RPh MS, Co Founder and Chief Clinical Officer of Sen-Jam Pharmaceutical (pictured on the right), whose work represents exactly the kind of forward- thinking, science-grounded solution the moment demands.
Sen-Jam is not another pharmaceutical company chasing the next symptomatic relief. Its platform, anchored by its proprietary PAIR Technology (Pleiotropic Anti-Inflammatory Regulators), seeks to modulate mast cells — the sentinels of the immune system that initiate inflammation. When mast cells overreact, they trigger a cascade of inflammation that not only drives chronic diseases like arthritis, neurodegeneration, cardiovascular disease, and metabolic syndrome but accelerates aging itself. “People think of inflammation as an annoyance,” says Iversen. “But it’s the spark behind almost every chronic disease, every premature wrinkle, every degenerating organ system. And mast cells are holding the match.” Unlike biologics, which suppress immune pathways and often leave patients vulnerable to infections, Sen-Jam’s approach works with the immune system to prevent inflammation from becoming pathological. This is not just disease management — it is health preservation.
And the pipeline is deep. Beyond the core PAIR platform, Sen-Jam has multiple near-term assets ready for licensing or partnership, including:
This is precisely why the Global Passion Project summit is becoming a magnet for both innovators and policymakers. Designed to accelerate ideas that advance health, beauty, and longevity, the summit brings together entrepreneurs, investors, scientists, and now, perhaps, government decision-makers.
Adding further dimension to the summit was filmmaker and keynote speaker Sean Stone, whose upcoming documentary explores the rise of Robert F. Kennedy Jr. as the new U.S. Secretary of Health and Human Services. The film continues a lineage of fearless truth-telling passed down from his father, legendary director Oliver Stone, whose JFK Revisited re-examined the forces behind America’s health and political crossroads. Speaking at the summit alongside Jackie and Jim Iversen and other leading innovators, Stone underscored the moment’s deeper resonance:
Filmaker Sean Stone being interviewed by Global Passion Project Founder and CEO, Andrea Cartier Bartzen at their recent West Palm Beach Event, co-sponsored by Sen-Jam Pharmaceutical
“We’re witnessing a rebirth—not just of healthcare, but of consciousness. What RFK Jr. represents isn’t just political—it’s personal, historical, and spiritual. This is a continuation of a legacy that questions institutional power and insists on truth, no matter how uncomfortable. The Global Passion Project, and innovators who are here to share their views, are carrying that torch by daring to reimagine what healing can be— before the damage is done.”
Sean Stone
This spirit of integration and elevation—across systems, ideas, and solutions—is precisely what made the summit a catalytic force. And for rising stars like Sen-Jam Pharmaceutical, it was more than a platform. It was a launchpad.
Kennedy’s charge to find rapid solutions may prove to be the catalyst this field has needed. For innovators like Sen-Jam, whose portfolio is poised for near-term commercialization, the moment could not be more aligned. And for the elite audience convening at the Global Passion Project — those who have long sought to extend vitality, beauty, and health span for themselves — it offers a larger, more meaningful vision: the chance to help turn the tide for an entire nation. Beauty, vitality, and longevity are not luxuries. They are now at the heart of a national imperative.
Sen-Jam Pharmaceutical is a clinical-stage biotech company co-founded by Jackie Iversen, RPh, MS, who serves as its Chief Clinical Officer. Sen-Jam is on a mission to end sickcare by addressing inflammation at its source—before symptoms ever begin. With its proprietary PAIR (Pleiotropic Anti-Inflammatory Regulators) platform, Sen-Jam focuses on upstream modulation of mast cells, targeting the root cause of inflammation to preserve health and vitality. Its growing portfolio spans viral illness, overindulgence, and opioid withdrawal—common conditions with uncommon solutions. In partnership with Global Passion Project, Sen-Jam helped co-create and lead the 2025 Palm Beach Health Summit, spotlighting mast cell modulation as a breakthrough frontier in both beauty and longevity science.
For more information, reach out at: Christine@sen-jam.com
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