Opioid withdrawal punishes the body with a surge of mast-cell–driven pain, gut upset, and anxiety that sends many patients back to fentanyl or buprenorphine swaps. SJP-005 delivers opioid-sparing, non-opioid relief instead of yet another substitution drug. Its NSAID + mast-cell-modulator pairing calms the inflammatory rebound and dulls pain, aiming to shorten detox stays, raise completion rates, and set a gentler, drug-free course to long-term recovery.